Anti-melanogenic effects of Medicago sativa seed extracts on melanocytes.

ABSTRACT:

Objective

Alfalfa (Medicago sativa) is a prominent herbal treatment among Asian countries and its antioxidant and anti-inflammatory effects have already been generally elucidated. Excessive melanin synthesis is one of the major troubles in the cosmetics industry, thus such research has been extensively described. Here, we investigated the anti-melanogenic effects and molecular mechanisms of two types of alfalfa extracts: alfalfa ethanol precipitate (AEP) and alfalfa ethanol supernatant (AES).

Methods

The chemical composition of AEP and AES was analysed using HPAEC-PAD and LC-MS/MS. B16F10 cells and MNT-1 cells were used to demonstrate the inhibitory effect of two alfalfa seed extracts on melanin synthesis. The gene expression and protein levels of tyrosinase, tyrosinase-rela

SUBMITTER: Kim CR 

PROVIDER: S-EPMC12666729 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature