PEG-23 glyceryl distearate, a multifunctional skin-supporting material, upregulates the expression of factors associated with epidermal barrier and hydration.

ABSTRACT:

Objective

As the outermost organ of the human body, the skin plays a critical role in protecting against external agents and oxidative stress, as well as in preventing excessive water loss. Among its layers, the stratum corneum of the epidermis is central to both barrier function and moisture retention, with its structural integrity significantly influencing skin health and appearance. Polyethylene glycol-23 glyceryl distearate (GDS-23) can form niosomes, liposome-like structures with multiple layers and serve as a carrier in drug delivery systems (DDS). We previously reported that GDS-23 exerts multiple biological effects, suppressing inflammation and enhancing the endogenous antioxidant system via Nrf2 activation through phosphorylation of the autophagy adaptor protein p62. In th

SUBMITTER: Miyoshi T 

PROVIDER: S-EPMC12666733 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature