Effect of the Food Matrix on the Survival to the Gastrointestinal Transit of Lacticaseibacillus rhamnosus CRL1505: A Randomized, Controlled, Crossover Study.

ABSTRACT: Probiotic survival is crucial for their beneficial effect, but only a few studies have assessed the impact of delivery format on probiotic viability after passage through the gastrointestinal tract.Our study aimed to investigate the survival of Lacticaseibacillus rhamnosus (L. rhamnosus) CRL1505 through the gastrointestinal transit in healthy volunteers after a daily consumption of at least 1 billion CFUs per day administered as freeze-dried cells or incorporated into oat- and milk-fermented drinks. The probiotic's survival was evaluated by combining culture-based and molecular techniques. Our findings revealed that L. rhamnosus CRL1505 survival was significantly higher when the probiotic was administered as an oat- and as a milk-fermented drink. The study highlighted the persistence of CR

SUBMITTER: Mangieri N 

PROVIDER: S-EPMC12666742 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature