Short-Term Alcohol Consumption Is Sufficient to Disrupt Microbial Communities and the Intestinal and Circulating Metabolites in a Non-Human Primate Model.

ABSTRACT: The gut microbiome is a complex and dynamic community of microorganisms that play a crucial role in maintaining host health and facilitating inter-organ communication. The microbiome is altered by the exposome, a phenomenon known as dysbiosis. Alcohol misuse can disrupt the gut microbial community in a dose- and duration-dependent manner. Previous studies showed that chronic alcohol misuse can induce intestinal hyperpermeability and significantly shift microbial communities. However, these data were obtained primarily from cross-sectional clinical and rodent-based studies following long-term chronic alcohol consumption. Clinical studies often utilize samples from patients with alcoholic liver disease and are confounded by variability in factors that can modulate the microbiome and reliance

SUBMITTER: Blanton MB 

PROVIDER: S-EPMC12666761 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature