Recipient-focused interventions to increase vaccine uptake in high and upper-middle income countries: a systematic review and network meta-analysis.

ABSTRACT:

Background

Vaccination is a highly effective public health tool. However, uptake of many vaccines has declined globally over the past decade, exacerbated by the COVID-19 pandemic, with coverage often falling short of critical thresholds. There is a large evidence-base of vaccine uptake interventions targeting vaccine recipients. Here we aim to synthesise evidence on the comparative effectiveness of these interventions, assess variations by age, and evaluate the impact of the COVID-19 pandemic on intervention effectiveness.

Methods

We conducted a systematic review, searching nine databases and grey literature for randomised controlled trials from high and upper-middle income countries, published from 2000 to April 2024. We included interventions targeted at vaccine recipients

SUBMITTER: Davies SR 

PROVIDER: S-EPMC12666792 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature