A standardized, open-source, portable model for noninvasive joint injury in mice.

ABSTRACT:

Objective

Preclinical models of osteoarthritis (OA) are crucial for the study of disease mechanisms and development of disease-modifying therapeutics. While surgical OA models, such as destabilization of the medial meniscus (DMM), have been the gold standard in the field for decades, noninvasive joint loading-based models have increased in popularity and utility. To facilitate standardization of the noninvasive anterior cruciate ligament rupture (ACLR) model in mice, we present the Mobile Joint-Injury Operator (MoJO) - an open-source protocol with accompanying fixtures and data, designed for a low-cost, commercially-available, portable, small-footprint uniaxial testing system.

Methods

We provide 3d-printable fixture designs and a comprehensive des

SUBMITTER: Newton MD 

PROVIDER: S-EPMC12666826 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature