Genome-wide cross-trait analysis of heterogeneous outcomes in early life atopic dermatitis.

ABSTRACT:

Background

Pediatric atopic dermatitis exhibits substantial heterogeneity in presentation, course, and long-term outcomes resulting in distinct phenotypes. Yet, genetic studies of atopic dermatitis have focused on a single trait or outcome and thus may not fully reveal underlying genetic relationships.

Objective

To identify novel genetic associations with early-life atopic dermatitis traits and evaluate shared genetic architecture across heterogeneous quantitative outcomes using a genome-wide cross-trait approach.

Methods

Children (n = 601) participating in the Mechanisms in the Progression of Atopic Dermatitis to Asthma in Childhood were genotyped and association was performed for each of 12 traits. Pleiotropy analyses were used to organize genetically similar traits

SUBMITTER: Martin LJ 

PROVIDER: S-EPMC12667001 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature