Efficacy of a Combined Natural Extract of Turmeric (Curcuma longa) and Liquorice (Glycyrrhiza uralensis) Against Viral Haemorrhagic Septicaemia Virus in Olive Flounders (Paralichthys olivaceus).

ABSTRACT: Viral haemorrhagic septicaemia virus (VHSV) causes a high mortality rate in cultured olive flounder, and effective treatment for VHSV infection is urgently required. Turmeric (Curcuma longa ) and liquorice (Glycyrrhiza uralensis) are well-known medicinal plants with a variety of biological activities. Turmeric and liquorice extract combination (TLex), containing 12 g glycyrrhizin and 0.72 g curcumin per litre, exhibited low cytotoxicity (CC₅₀: 7903.08 ± 6.26 μg/mL) and potent antiviral activity (EC₅₀: 149.4 ± 2.34 μg/mL) in hirame natural embryo (HINAE) cells. Plaque reduction assays indicated that post-exposure treatment was most effective, with antiviral efficacy increasing over time. Additionally, TLex at 133.4 μg/mL upregulated antiviral genes (Mx, ISG15, IRF3 and

SUBMITTER: Shin SM 

PROVIDER: S-EPMC12667007 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature