Primary aldosteronism: pharmacotherapy <i>vs</i> surgery <i>vs</i> embolization efficacy - systematic review and network meta-analysis of studies predominantly conducted in China.

ABSTRACT:

Background

Primary aldosteronism (PA) is one of major cause of resistant hypertension. This study compares the efficacy and safety of current treatments, including pharmacotherapy, adrenalectomy, and minimally invasive techniques, to guide clinical practice.

Method

We systematically searched Embase, PubMed, Cochrane, Web of Science, CNKI, Wanfang, and VIP from inception to August 13, 2024, for randomized controlled trials and cohort studies involving adult patients with PA and hypertension. Reporting quality of the included studies was assessed using the Cochrane Risk of Bias 2 tool for RCTs and the Newcastle-Ottawa Scale (NOS) for cohort studies. Data analysis was performed using R 4.3.3 and STATA 15.0.

Results

This study included 17 articles involving 1,496 patients

SUBMITTER: Li G 

PROVIDER: S-EPMC12667026 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature