The mutagenic forces shaping the genomes of lung cancer in never smokers.

ABSTRACT: Lung cancer in never smokers (LCINS) accounts for around 25% of all lung cancers^1,2 and has been associated with exposure to second-hand tobacco smoke and air pollution in observational studies^3-5. Here we use data from the Sherlock-Lung study to evaluate mutagenic exposures in LCINS by examining the cancer genomes of 871 treatment-naive individuals with lung cancer who had never smoked, from 28 geographical locations. KRAS mutations were 3.8 times more common in adenocarcinomas of never smokers from North America and Europe than in those from East Asia, whereas a higher prevalence of EGFR and TP53 mutations was observed in adenocarcinomas of never smokers from East Asia. Signature SBS40a, with unknown cause⁶, contributed the largest proportion of single ba

SUBMITTER: Diaz-Gay M 

PROVIDER: S-EPMC12667038 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature