The impact of single-nucleotide variants of hepatitis B virus and antiviral on liver cancer in gray zone patients.

ABSTRACT:

Objectives

This study investigated the impact and related mechanisms of single-nucleotide variants (SNVs) in the HBV pre-S/S region on tumor development, and evaluated the role of antiviral therapy.

Methods

A retrospective analysis was conducted in 104 patients of the gray zone. HCC-associated SNVs were analyzed in baseline samples.

Results

HCC occurred in 15 patients (14.4%) during the median follow-up period of 10.4 years. Genotype B HBV-infected HCC patients had more T53C, A273G, and A529G SNVs and genotype C HBV-infected HCC patients had more T53C, G633A, and A3120G SNVs than HCC-free groups. Antiviral therapy reduced the risk of HCC in patients with HCC-associated SNVs in the gray zone both genotype B or C. Ectopic expression of replication-competent HBV plasmids

SUBMITTER: Teng W 

PROVIDER: S-EPMC12667080 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature