Joint association of inflammatory markers and sedentary time with mortality in metabolic dysfunction-associated steatotic liver disease population and the mediating role of inflammation.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health burden globally, associated with multiple adverse outcomes and increased mortality. Sedentary behavior and systemic inflammation are independently linked to adverse outcomes, but their combined effects and potential interactions in the MASLD population remain unclear.

Methods

We used data from 10,778 U.S. adults with MASLD from NHANES 2007-2018. MASLD was identified using the Fatty Liver Index (FLI ≥ 60), a validated and widely applied noninvasive indicator of hepatic steatosis in NHANES-based epidemiologic studies, providing a reliable estimate of liver fat probability for population analyses. Sedentary time was assessed by questionnaire. The systemic inflammation response

SUBMITTER: Xu LB 

PROVIDER: S-EPMC12667099 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature