Imbalance, compensation, and rigidity in brain functional connectivity and microstates among older adults with cognitive impairment.

ABSTRACT:

Objective

This study seeks to analyze the coordinated patterns of spontaneous neural activity and instantaneous electrical activity in the brain using dual-dimensional indicators of brain functional connectivity and microstates, aiming to identify potential biomarkers for early screening and precise classification.

Methods

A case-control study design was utilized, with 195 older adults suffering from cognitive impairment (with a roughly equal distribution of mild and moderate cases) serving as the case group, and 65 healthy older adults matched as the control group. Participants were required to complete a demographic questionnaire, the Montreal Cognitive Assessment Scale, the short form of the International Physical Activity Questionnaire, and the Pittsburgh Sleep Quality I

SUBMITTER: Ding F 

PROVIDER: S-EPMC12667136 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature