Exploratory analysis of the molecular and genomic landscape of upper tract urothelial carcinoma using long-read sequencing.

ABSTRACT:

Background

Upper tract urothelial carcinoma (UTUC), including renal pelvic urothelial carcinoma and ureter urothelial carcinoma, accounts for 10% of urothelial carcinoma (UC). Poorer outcomes and different genetic characteristics of UTUC were reported compared to urothelial carcinoma of the bladder (UCB), which accounts for most cases of UC. Therefore, there is an urgent need for the development of molecular characterization and precision therapies tailored specifically for UTUC.

Methods

To elucidate the genetic landscape of UTUC, we included 4 UTUC samples in this study and also perform next-generation sequencing (NGS) of whole exome sequencing. After that, long-read sequencing (LRS) was employed to conduct Whole genome sequencing (WGS) analyses on tumor samples obtained fr

SUBMITTER: Shang Z 

PROVIDER: S-EPMC12667143 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature