Antiemetic use during pregnancy and child neurodevelopment: population-based birth cohort study.

ABSTRACT:

Background

Antiemetics are commonly prescribed for nausea and vomiting during pregnancy (NVP), affecting up to 80% of pregnant women. However, data on their long-term neurodevelopmental effects are limited. We therefore aimed to assess the risk of neurodevelopmental disorders and delays in children exposed to antiemetics commonly prescribed during pregnancy.

Methods

This nationwide cohort study, designed to emulate a pragmatic trial, used South Korea's National Health Insurance Service mother-child linked database, 2009-2023. The primary exposure of interest was metoclopramide, while pyridoxine, doxylamine, dimenhydrinate, domperidone, and ondansetron were included in secondary analyses. Non-exposed pregnancies within the cohort served as comparators. The outcomes included s

SUBMITTER: Cho Y 

PROVIDER: S-EPMC12667158 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature