A model of the cerebellum generates gait adaptations in a reflex-based neuromusculoskeletal model during split-belt walking.

ABSTRACT:

Background

During split-belt treadmill walking, neurotypical humans exhibit adaptations characterized by a gradual decrease in step length asymmetry (SLA) toward or beyond symmetry, whereas individuals with cerebellar damage do not show these motor adaptations. Neuromusculoskeletal simulations may help to better understand individual aspects of the underlying neural control, but are currently incapable of predicting adaptations to the continuous perturbations imposed by split-belt walking.

Methods

We extend a spinal reflex model with a biologically inspired model of the cerebellum, which enables error-based motor adaptation by modulating spinal control parameters in response to mismatches between a continuously updated internal prediction and actual motor outcomes. In this w

SUBMITTER: Fleischmann S 

PROVIDER: S-EPMC12667192 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature