High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer.

ABSTRACT: Fifteen percent of patients with preoperative stage IA2-IB1 uterine cervical cancer are diagnosed with lymph node metastasis (LNM) following surgery. They must be treated with both surgery and radiotherapy, a combination associated with severe side effects. Since current diagnostic methods have limitations, biomarkers are urgently needed to improve staging. Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is a regulator of growth factor signaling and a prognostic factor in cervical cancer. This study investigates whether LRIG1 expression could predict LNM in cervical cancer. Sixty-seven patients were included: 31 without LNM and 36 with LNM. Tumor blocks were retrieved, and clinical data were collected. Immunohistochemical analysis of LRIG1 expression was performed, a

SUBMITTER: Israelsson P 

PROVIDER: S-EPMC12667210 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature