Pathology of a Canine Model of Localized Prostate Carcinoma.

ABSTRACT:

Background

Dogs spontaneously develop prostate carcinoma (PC) and share prostate gland anatomy, physiology, and size to men. Over the last 15 years, we have developed and refined a canine model of focal PC to evaluate therapeutic-diagnostic (theranostic) interventions. A comprehensive description of the pathology and synthesis of the various studies has not been performed. The goal of this manuscript was to describe the canine model tumor pathology within the framework of its methodological development to help guide future translational PC research.

Methods

In published and unpublished studies, we previously inoculated prostate glands of immunosuppressed, intact beagle dogs (n = 56) with a canine PC cell line (Ace-1) transduced with human or canine genes for targeted therano

SUBMITTER: Hoggard NK 

PROVIDER: S-EPMC12667227 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature