Impact of prophylactic bilateral salpingo-oophorectomy in patients with colorectal cancer with peritoneal metastasis during cytoreductive surgery: dual-center cohort analysis.

ABSTRACT:

Background

Ovarian metastases are common in patients with colorectal cancer (CRC) with peritoneal metastases. For patients with bilateral macroscopically normal ovaries, prophylactic bilateral salpingo-oophorectomy (BSO) remains controversial. This study assessed the survival benefit of prophylactic BSO during cytoreductive surgery (CRS).

Methods

This retrospective cohort study included patients with CRC with peritoneal metastases who underwent CRS at two medical centres in southern China between 2017 and 2022. Patients achieving complete CRS with bilateral macroscopically normal ovaries were included in the subsequent analysis and divided into BSO and non-BSO groups. The primary outcomes of interest were the rates of synchronous and metachronous ovarian metastases. Clinical

SUBMITTER: Xue X 

PROVIDER: S-EPMC12667262 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature