New antifungal chlorinated orsellinic aldehydes from the deep-sea-derived fungus <i>Acremonium sclerotigenum</i> LW14.

ABSTRACT: Two new pairs of chlorinated orsellinic aldehyde enantiomers acresorcinols A and B (1a/1b and 2a/2b), and three orsellinic aldehydes, acresorcinols C-E (3-5) were discovered from the extract of the deep-sea-derived fungus Acremonium sclerotigenum LW14. Their structures, including absolute configurations, were experimentally elucidated by spectroscopic analysis, NMR calculations with DP4+ probability analysis, and ECD calculations. Compounds 1 and 2 exemplify the first reported chlorinated orsellinic aldehydes, characterised by a distinctive 6/5-5 tricyclic core structure with a bridged framework. Acresorcinol C (3) was a rare carbon-bridged resorcinol dimer via a methylene bridge. The bioassay results showed that all com

SUBMITTER: Huo R 

PROVIDER: S-EPMC12667284 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature