Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1⁺/Itga11⁺ Fibroblast Patterning Promotes Axon Growth after Spinal Cord Injury.

ABSTRACT: Fibrotic scarring remains a critic obstacle to axonal regeneration after spinal cord injury (SCI). Current strategies primarily concentrating on eliminating extracellular matrix (ECM) components neglect their dispensable roles in maintaining tissue integrity. Here, it is reported that the mechanical strength of an integrated hydrogel composed of hyaluronic acid-graft-dopamine and HRR peptide directs fibroblast migration, determining ECM deposition. The mechanical strength matching that of spinal cord induces fibroblast alignment, reshaping fibrotic scars into a parallel matrix, while the mechanical strength deviating from that of spinal cord fails to do so. Mechanical investigation identifies a previously unknown Il11ra1⁺/Itga11⁺ fibroblast subset that is specially as

SUBMITTER: Xiao L 

PROVIDER: S-EPMC12667452 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature