Engineered Substrate-Free Small Molecules for Enhanced Raman Scattering and Photothermal Conversion Efficiency.

ABSTRACT: Raman spectroscopy with surface-enhanced Raman scattering (SERS) through metal substrates is a highly precise bioimaging technique. Alternatively, recently discovered small molecules to enhance the Raman signal intensities through their self-stacking, termed stacking-induced intermolecular charge transfer-enhanced Raman scattering (SICTERS), offer ultrasensitive in vivo Raman imaging free of substrates. Molecular engineering to increase the SICTERS intensity and to tune photothermal conversion efficiency of these molecules is critical for furthering their biomedical application but not yet feasible. Here, by increasing the length of side chain and introducing the benzene ring to bis-thienyl-substituted benzobisthiadiazole, this study demonstrates an optimized molecule BBTPPRO that possesse

SUBMITTER: Yu S 

PROVIDER: S-EPMC12667519 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature