Virulence-Selective Trap-Capture-Kill Antibacterial Nanostructures With Immune-Metabolic Regulation for Treating Implant-Associated Infections.

ABSTRACT: The treatment of orthopedic implant-associated infections (IAIs) presents significant challenges due to increasing drug resistance. This study reports a virulence-selective trap-capture-kill antibacterial system for effectively treating persistent infections while promoting local bone tissue regeneration by regulating disordered immune and metabolic microenvironments caused by IAIs. Here, this work fabricates a nanostructured antibacterial system (F-14-TNA) based on a TiO₂ nanotube array modified with a cationic pentacyclic coplanar backbone, fascaplysin derivative 14 (F-14). The modified surface induces a unique virulence-initiated chemotaxis behavior, with the TiO₂ nanostructure selectively trapping hyperpathogenic bacterial strains from the infecting microbiota. Th

SUBMITTER: Hu X 

PROVIDER: S-EPMC12667538 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature