Microglia Drive Peripapillary Vascular Density Reduction in Normal Tension Glaucoma by Regulating the Rpl17/Stat5b/Apoa1 Axis.

ABSTRACT: Normal tension glaucoma (NTG) is a predominant subset of glaucoma in Asia and is characterized by glaucomatous optic neuropathy in the absence of elevated intraocular pressure. Alterations in retinal blood vessels are reported to be important mechanisms of glaucomatous optic nerve damage. Retinal peripapillary vascular density is assessed in patients with early stage NTG and OPTN (E50K) mutant mice and confirmed a similar reduction in retinal peripapillary vascular density in patients with NTG and model mice. Thus, identifying the mechanisms underlying retinal vascular changes in NTG is crucial for developing effective therapeutic strategies. This study revealed that Rpl17 is upregulated in the retinal microglia of OPTN (E50K) mutant mice. Rpl17 exerts regulatory control over Apoa1 by dire

SUBMITTER: Zhang D 

PROVIDER: S-EPMC12667541 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature