Impacts of Polyenvironmental Factors on DNA Methylation in Patients With Psychosis.

ABSTRACT:

Background

Only a few studies have investigated the association of environmental factors with DNA methylation in schizophrenia (SZ). Our study sought to investigate differentially methylated positions (DMPs) and differentially methylated regions (DMRs) between patients with psychosis and healthy controls (HCs) and to explore associations of aberrant methylation levels with the Korea-polyenvironmental risk score-I (K-PERS-I), a comprehensive tool measuring polyenvironmental risk factors for psychosis.

Study design

Blood-based methylome-wide association study (MWAS) was conducted in patients with psychosis (n = 414) and HCs (n = 225). For MWAS, a new cutting-edge technique, Methyl-Seq was employed. Using the K-PERS-I, polyenvironmental risk factors were assessed.

SUBMITTER: Rami FZ 

PROVIDER: S-EPMC12667615 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature