Asiatic acid, a novel ciprofloxacin adjuvant inhibits <i>Shigella flexneri</i> infection.

ABSTRACT: Bacterial infection caused by intracellular pathogens such as Shigella flexneri is a rapidly increasing global health concern that requires urgent and necessary action. The dearth of licensed vaccines against shigellosis and the decline in susceptibility to conventional antibiotics has encouraged the development of new antibiotic principles and drugs. The treatment options are decreasing faster than the discovery rate of new antibacterial agents. Combinatorial approach of antibiotics with non-antibiotic adjuvants is a promising aspect to treat resistant bacterial infections. Asiatic acid, a membrane-disrupting triterpenoid with wide antimicrobial and immunomodulatory properties, can potentiate antibiotics, but the exact mechanisms remain broadly unexplored. Therefore, in this study,

SUBMITTER: Maitra P 

PROVIDER: S-EPMC12667651 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature