Claudin-1 impairs blood-brain barrier by downregulating endothelial junctional proteins in traumatic brain injury.

ABSTRACT: Traumatic brain injury (TBI) is a leading cause of death and disability in patients. Brain microvasculature endothelial cells form the blood-brain barrier (BBB) which functions to maintain a protective barrier for the brain from the passive entry of systemic solutes. As a result of the cellular disruption caused by TBI, the BBB is compromised. Tight junction disruption in the endothelium of the BBB has been implicated in this response, but the underlying mechanisms remain unresolved. We utilized various in vivo models of severe to mild TBI as well as in vitro exposure of brain endothelial cells (bEND.3) to analyze conditions encountered following TBI to gain mechanistic insight into alterations observed at the BBB. We found that claudin-1 (CLDN1), was significantly increased

SUBMITTER: Gowrikumar S 

PROVIDER: S-EPMC12667667 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature