Colonization of the central nervous system as a key factor in the <i>Cryptococcus gattii</i> pathogenicity.

ABSTRACT: The Cryptococcus gattii species complex is one of the main etiological agents of cryptococcosis, a fungal infection that affects the lungs and progresses to meningoencephalitis. Neurological infections caused by this species are associated with a higher incidence of cryptococcoma, sequelae, and relapse. Despite its clinical relevance, the mechanisms that sustain the infection and persistence of C. gattii in the central nervous system (CNS) are still poorly understood. In this study, we performed a comprehensive phenotypic characterization of the virulence of five C. gattii strains, focusing on the CNS infectious biology. Significant differences in virulence among the strains were found, highlighting intracellular survival within macrophages and growth in the CNS as det

SUBMITTER: Cota Freitas GJ 

PROVIDER: S-EPMC12667668 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature