Prevalence and association testing of antinuclear antibodies and inflammatory bowel disease in Taiwan.

ABSTRACT:

Background

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are characterized by chronic inflammation of the gastrointestinal tract. Antinuclear antibodies (ANAs), which are autoantibodies directed against nuclear components, are commonly present in various autoimmune disorders. We investigated the prevalence and clinical significance of ANAs in Taiwanese patients with IBD.

Methods

From January 2017 to December 2024, ANA status was checked at initial diagnosis of IBD in patients from a medical center in central Taiwan. Risk factors for ANA positivity were evaluated.

Results

Of the 166 patients in this study, 57 had CD and 109 had UC. ANA test results were positive (titers of ≥ 1:160) in 26 patients (15.7%). Older age at dis

SUBMITTER: Yang TM 

PROVIDER: S-EPMC12667684 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature