Accurate detection of tandem repeats from error-prone sequences with EquiRep.

ABSTRACT: A tandem repeat is a sequence of nucleotides that appear as multiple contiguous, near-identical copies arranged consecutively. Tandem repeats are widespread across natural genomes, play critical roles in genetic diversity and gene regulation, and are associated with various neurological and developmental disorders. They can also arise in sequencing reads generated by certain technologies, such as those used for sequencing circular molecules. A key challenge in analyzing tandem repeats is reconstructing the sequence of the underlying repeat unit. Although several methods exist, they often exhibit low accuracy when the repeat unit length increases or the number of copies is low. Furthermore, methods capable of handling highly mutated sequences remain scarce, highlighting a significant opport

SUBMITTER: Song Z 

PROVIDER: S-EPMC12667709 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature