Joint imputation and deconvolution of gene expression across spatial transcriptomics platforms.

ABSTRACT: Spatially resolved transcriptomics (SRT) technologies measure gene expression across thousands of spatial locations within a tissue slice. Multiple SRT technologies are currently available and others are in active development, with each technology having varying spatial resolution (subcellular, single-cell, or multicellular regions), gene coverage (targeted vs. whole-transcriptome), and sequencing depth per location. For example, the widely used 10x Genomics Visium platform measures whole transcriptomes from multiple-cell-sized spots, whereas the 10x Genomics Xenium platform measures a few hundred genes at subcellular resolution. A number of studies apply multiple SRT technologies to slices that originate from the same biological tissue. Integration of data from different SRT technologies

SUBMITTER: Zheng H 

PROVIDER: S-EPMC12667712 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature