The Quorum Sensing-Controlled Competence Regulon Drives H₂O₂ Production in <i>Streptococcus gordonii</i>.

ABSTRACT: Streptococcus gordonii sp. firmicutes is an early colonizer of the oral microbiome and contributes positively to oral health. While this species has been found to produce hydrogen peroxide by spxB expression, the relationship of this expression to the competence regulon has not yet been explored. To this end, this study sought to investigate the connection of the S. gordonii competence regulon quorum sensing (QS) circuitry with downstream proliferative phenotypic expression resulting from competence-stimulating peptide (CSP) exposure, with specific attention to peroxide formation. Following confirmation of the native CSP, RNA-seq was completed to gain insights into transcriptomic variations resulting from CSP incubation. Later, structure-activity relationship (S

SUBMITTER: Brennan AA 

PROVIDER: S-EPMC12667739 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature