Myeloperoxidase impairs mucociliary transport on human airway epithelium.

ABSTRACT: Dampening neutrophil-driven inflammation in the airways remains a challenge in treating cystic fibrosis (CF) lung disease. Myeloperoxidase (MPO) is a neutrophilic enzyme that produces reactive oxygen species and is highly concentrated in CF sputum samples. Greater MPO concentrations have been previously correlated with increased mucus plugging in bronchiectasis, suggesting that the enzyme could impair mucociliary transport. MPO reacts competitively with either thiocyanate (SCN^-) or chloride (Cl^-) in the airways to catalyze the production of hypothiocyanous acid (HOSCN) or hypochlorous acid (HOCl), respectively. HOCl has proved in prior studies to be extremely cytotoxic, while HOSCN can drastically reduce cytotoxicity. The concentration of SCN^- in the airway

SUBMITTER: Boboltz A 

PROVIDER: S-EPMC12667835 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature