Unveiling the Multifaceted Networks of the Left DLPFC for Precision TMS Targeting.

ABSTRACT: The left dorsolateral prefrontal cortex (lDLPFC) is the standard target for transcranial magnetic stimulation (TMS) to ameliorate treatment-resistant depression (TRD), yet non-response rates remain high. TMS efficacy has been linked to the stimulation site's functional connectivity, particularly its anti-correlation with the subgenual cingulate cortex (SGC). While this pragmatic strategy has demonstrated clinical utility, it offers limited insight into how the lDLPFC's network interactions contribute to site-dependent variability in treatment response. Here, we used connectivity-based parcellation within an lDLPFC region encompassing common TMS targets and adjacent areas to delineate functional subdivisions and characterize their connectivity to large-scale networks and behavioral associat

SUBMITTER: Paas Oliveros LK 

PROVIDER: S-EPMC12667863 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature