<i>Trans</i>-acting mutations reveal non-nuclear modulators of both intrinsic and extrinsic gene expression noise in a eukaryote.

ABSTRACT: Gene expression regulation is a stochastic process that can be modified by mutations not only in a deterministic manner but also in a probabilistic way, for example by changing the extent of cell-to-cell variability in gene expression (also called "gene expression noise") without necessarily changing the expected (mean) expression level. Such mutations can act either in cis (perturbing expression noise at their own locus) or in trans (perturbing expression noise of a gene located elsewhere in the genome). Although systematic studies have successfully analyzed the properties of cis-acting mutations modulating gene expression noise, less is known about the type of genetic changes that may alter expression noise in trans. Here, we applied genetic mapping on yeast s

SUBMITTER: Martin N 

PROVIDER: S-EPMC12667888 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature