CD8ɑ+ cells suppress SIV replication without evidence of viral immune escape during post treatment control.

ABSTRACT: Post-treatment control (PTC) is a rare phenomenon in which people living with HIV (PLWH) maintain viral control following ART interruption. Characterizing virus populations present in PTCs may help elucidate mechanisms of immunologic control, but this is challenging without detectable plasma viremia. To model PTC, eight Mauritian cynomolgus macaques (MCM) were infected with barcoded SIVmac239M and began an 8-month ART regimen two weeks post-infection (wpi). Six months following ART interruption, all MCM were rechallenged with non-barcoded SIVmac239 followed by CD8ɑ+ cell depletion two months later. Animals were grouped as viremic (n=5) or aviremic (n=3) based on the detection of plasma viremia between ART interruption and CD8ɑ+ cell depletion; all animals became viremic post-depletion. Bar

SUBMITTER: Moriarty RV 

PROVIDER: S-EPMC12667943 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature