Harmonized Protocol for Segmentation of the Hippocampal Tail on High-Resolution <i>in vivo</i> MRI from the Hippocampal Subfields Group (HSG).

ABSTRACT: The hippocampus is a heterogeneous structure with cytoarchitectonically distinct subfields that exhibit heterogeneous lifespan trajectories and are differentially susceptible to diseases. Advances in high-resolution imaging have accelerated research on these structures, yet variability in segmentation protocols limits cross-study comparability. The Hippocampal Subfields Group (HSG) is an international consortium addressing this challenge by developing a reliable, accessible, and freely available segmentation protocol for high-resolution T2-weighted 3 tesla MRI scans (http://www.hippocampalsubfields.com). Here, we present the harmonized protocol for the posterior portion of the hippocampus (the "tail"), complementing the previously established "body" protocol, and with an anterior "head" pr

SUBMITTER: de Flores R 

PROVIDER: S-EPMC12667945 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature