Predicting the invasiveness of threshold-dependent gene drives.

ABSTRACT: Gene drives hold great promise for controlling disease vectors or invasive species due to their capacity to rapidly spread through a population from a small initial release. This same property also raises serious concerns about unintended spillover into non-target populations. Threshold-dependent gene drive systems, which can spread only when introduced above a critical population frequency, have been proposed as a more controllable alternative, yet their invasion dynamics in spatially structured populations remain poorly understood. Here, we analyze invasion criteria for threshold-dependent gene drives in continuous-space populations using deterministic reaction-diffusion models and individual-based simulations that better capture the stochasticity of real-world populations. We find subst

SUBMITTER: Kim IK 

PROVIDER: S-EPMC12667978 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature