The HosA histone deacetylase regulates stress resistance, host cell interactions, and virulence in <i>Aspergillus fumigatus</i>.

ABSTRACT: The capacity of Aspergillus fumigatus to cause invasive pulmonary aspergillosis depends on its ability to adapt to dynamic and stressful microenvironments within the host. Epigenetic regulation, including histone deacetylation, plays a critical role in fungal adaptation to stress. Here, we investigated the role of the class I histone deacetylase (HDAC) HosA in A. fumigatus stress resistance, host cell interactions, and virulence. A ΔhosA mutant had increased susceptibility to intracellular oxidant stress induced by menadione. It also had impaired capacity to invade and damage two pulmonary epithelial cell lines in vitro. In a corticosteroid-immunosuppressed mouse model of invasive aspergillosis, mice infected with the ΔhosA mutant survived significantly l

SUBMITTER: Liu H 

PROVIDER: S-EPMC12667980 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature