Proline transporters balance the salicylic acid-mediated trade-off between regeneration and immunity in plants.

ABSTRACT: A robust immune response and regenerative capacity are both essential for survival after injury. In plants, salicylic acid (SA) is essential for activating immunity but simultaneously suppresses regenerative capacity. The mechanisms coordinating the trade-off between immunity and regeneration remain poorly understood. Here, we identify proline transporters as key regulators of this balance. Mutations in two wound-induced proline transporters, ProT2 and ProT3, rescued exogenous proline-induced suppression of de novo root regeneration (DNRR) and enhanced DNRR. ProTs are required for SA-mediated suppression of regeneration, without affecting SA-dependent defense responses. Mechanistically, a ProT3-CPK1 complex modulates the dynamics of wound-induced reactive oxygen species (ROS), sustaining a

SUBMITTER: Xu D 

PROVIDER: S-EPMC12667995 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature