CNS Myelin Sheath Lengths Locally Scale to Axon Diameter via Piezo1.

ABSTRACT: Myelin sheath lengths vary by an order of magnitude in the central nervous system (CNS) and tune the timing of neuronal signaling. Thus, variation in myelin sheath length has been proposed to coordinate the timing of neuronal signaling to ultimately impact behavior. The mechanisms to establish myelin sheath length are unknown. For decades, reports have documented that in vivo myelin sheath size scales with the diameter of the ensheathed axon. We previously demonstrated diameter is sufficient to instruct myelin sheath lengths formed by oligodendrocytes using a synthetic axon culture system. The mechanisms of oligodendrocyte diameter-sensing and its translation into sheath elongation are still unknown. Here we demonstrate that diameter-sensing and sheath length is locally regulated: each ind

SUBMITTER: Young AR 

PROVIDER: S-EPMC12668015 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature