The Impact of Insulin Resistance on Grey Matter Changes Along the Alzheimer's Disease Continuum Insulin Resistance and Grey Matter in AD.

ABSTRACT:

Background and objectives

Insulin resistance is emerging as a modifiable risk factor for Alzheimer's, though its impact on grey matter volume across clinical stages remains poorly understood. The objective of the research is to investigate how insulin resistance affects grey matter integrity across the Alzheimer's disease continuum using structural MRI.

Methods

Imaging, clinical, and metabolic data were extracted from 374 non-diabetic participants within the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. Participants were classified as cognitively impaired (CI: n=186; 137 mild cognitive impairment, 49 early-to-moderate dementia; all AD biomarker positive) or cognitively unimpaired (CU: n=188; 122 amyloid-negative, 66 amyloid-positive). Insulin resistance was ass

SUBMITTER: Bettonagli V 

PROVIDER: S-EPMC12668048 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature