ClinPreAI: An Agentic AI System for Early Postpartum Depression Risk Prediction from Multimodal EHR Data.

ABSTRACT: Postpartum depression (PPD) affects 10-15% of individuals annually, yet early identification and treatment remains challenging. We introduce ClinPreAI, a novel agentic AI system that autonomously designs, implements, and evaluates machine learning solutions for PPD risk prediction using multimodal electronic health record data. We analyzed data from 4,161 pregnant individuals hospitalized prior to delivery for medical or obstetrical complications at Texas Children's Hospital (2012-2025), extracting 27 structured clinical variables and social worker notes. The primary outcome was Edinburgh Postnatal Depression Scale (EPDS) score ≥10 (31.0% prevalence) within 6 months after delivery, indicating clinically significant depressive symptoms. ClinPreAI operates through five specialized modules th

SUBMITTER: Palacios D 

PROVIDER: S-EPMC12668105 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature