Superhydrophilic Fe^IV ₂Mn^II Nanocluster: A Combined Diagnostic and Therapeutic Agent.

ABSTRACT: We report here an atomically precise nanocluster, (NH₄)₂Mn^II(H₂O)₂[Fe^IV(L)]₂·11H₂O (Fe₂Mn). This system was designed to harness superhydrophilic interactions to enhance magnetic resonance imaging (MRI), while permitting photoacoustic imaging (PAI) and photothermal antitumor therapy. It was synthesized using Fe-HDCL, an Fe(IV) system with strong near infrared (NIR) photothermal conversion capabilities, as a precursor and manganese(II) ion that allows for MRI as the metal center. Fe₂Mn not only produces a useful photothermal effect but also provides for MRI enhancement with a longitudinal relaxivity (r₁) of 7.67 mM^-1s^-1 at 0.5 T and 6.02 mM^-1

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12668307 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature