EDA Complex-Driven Desaturation of Heterocyclic Carbonyl Compounds Enabled by HFIP.

ABSTRACT: Recently, electron donor-acceptor (EDA) complex-mediated organic synthetic strategies have emerged as powerful tools for diverse bond-forming transformations; however, their efficiency often diminishes when ionic reactants are involved. This limitation arises from the requirement of polar solvents such as DMSO or DMF to solubilize ionic species for the formation of effective EDA complex. Consequently, these solvents engage in competing EDA complex formation or disrupt ionization equilibria. In parallel, there is a pressing necessity of modern and efficient strategy to achieve dehydrogenation reactions, which are in general limited by the drawbacks of traditional approaches. To address both, herein, we disclose an innovative desaturation strategy based on the formation of an EDA complex bet

SUBMITTER: Maiti R 

PROVIDER: S-EPMC12668311 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature