Nickel-Catalyzed Asymmetric α-Alkenylations of Acyclic Amides that Provide Tertiary Stereocenters.

ABSTRACT: Carbonyl groups and alkenes are ubiquitous in organic chemistry─present in target molecules as well as versatile handles for conversion into other functional groups. Whereas the coupling of the α position of a carbonyl compound with an alkenyl electrophile represents an attractive approach to uniting these useful functionalities, to date there have been few reports of catalytic asymmetric variants of this bond construction. Most of the progress to date has involved cyclic carbonyl compounds (obviates the issue of controlling the E/Z geometry of the nucleophile) and the generation of quaternary stereocenters (obviates undesired side reactions of the β,γ-unsaturated carbonyl product, such as racemization or isomerization to the more stable α,β-unsaturated carbonyl compound). He

SUBMITTER: Hossain A 

PROVIDER: S-EPMC12668401 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature