Investigating the mechanism of oridonin against triple-negative breast cancer based on network pharmacology and molecular docking.

ABSTRACT: Oridonin, a tetracyclic diterpenoid from Rabdosia rubescens (Hemsl.) Hara, exhibits various pharmacological actions, such as anti-tumor, anti-infective, and anti-inflammatory properties. However, the underlying pharmacological effects of oridonin on triple-negative breast cancer (TNBC) are yet to be elucidated. This study aims to examine the molecular mechanism and pharmacological impact of oridonin on TNBC using a network pharmacological strategy. Initially, the pharmacological databases and analysis platforms were employed to identify the potential targets of oridonin using the GeneCards website. The process of standardizing gene names involved the conversion of all target genes using the UniProt database. The acquired data was subjected to identify prevalent target genes. Then, these ge

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12668475 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature