Integrated multi-omics analysis reveals necroptosis-related biomarker BIRC3 for early diagnosis and therapeutic targeting in preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) is a life-threatening pregnancy disorder lacking reliable early biomarkers. While apoptosis is implicated in PE pathogenesis, the role of regulated necrotic cell death (necroptosis) remains poorly understood. This study aimed to identify necroptosis-related biomarkers, and further provide the potential natural compounds for PE with virtual screening.

Methods

Public datasets (GSE66273 for training set; GSE44711 for validation set; GSE173193 for single-cell RNA-seq) were analyzed. Differentially expressed genes (DEGs) were screened using limma (|log2FC| > 1, P < 0.05). Necroptosis-related genes overlapped with DEGs to identify key candidates. Subsequent analyses included machine learning, protein-protein interaction (PPI) network construction, and

SUBMITTER: Lin Q 

PROVIDER: S-EPMC12668491 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature