Second-line treatment strategies of ulcerative colitis after conventional therapy failure: A systematic review and network meta-analysis of randomized controlled trials.

ABSTRACT:

Purpose

This study aimed to compare the efficacy and safety of pharmacotherapies for ulcerative colitis (UC), promoting more precise management of refractory ulcerative colitis.

Methods

Relevant randomized controlled trials involving refractory UC patients were systematically searched in electronic databases, including MEDLINE, EMBASE, and the Cochrane Library. Data were independently extracted by three investigators. Risk ratios (RRs) with 95% confidence intervals (CI) were calculated for key outcomes: remission, response, mucosal healing, and serious adverse events using random-effects models. Network meta-analysis, utilizing a frequency model, established comparative rankings, with surface under cumulative ranking curve (SUCRA) determining optimal treatments.

Results</

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12668551 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature