External Validation of the Fraser Equation for Estimation of Free Valproate Concentrations in Critically Ill Adults.

ABSTRACT:

Background

Critically ill patients may be overexposed to valproate because altered protein binding leads to a disproportionate free valproate fraction. The Fraser equation was derived and internally validated to estimate critically ill patients' free valproate concentrations, but it requires external validation.

Methods

Adult intensive care unit (ICU) patients at two academic centers with concurrently measured free and total valproate concentrations were included. Free valproate concentrations were estimated using the Fraser equation which includes total valproate, albumin and BUN concentration, and whether the patient received propofol or aspirin. The primary outcome was Fraser equation performance, assessed using Bland-Altman methods. Comparative performance against estima

SUBMITTER: Webb AJ 

PROVIDER: S-EPMC12668601 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature